Isosorbide nitrate tablets and nitroglycerin can’t be assessed as good or bad, both can be used for the treatment of angina pectoris, but the specific route of administration is different. Isosorbide nitrate tablets are mainly administered orally, with the effect of dilating coronary arteries, patients with angina can be routinely treated with oral isosorbide nitrate, subject to the half-life of the drug, which needs to be taken three times a day. Nitroglycerin belongs to the fast-acting preparation, mainly used for angina pectoris first aid, the use of sublingual, can quickly play the role of coronary artery dilation, but the duration of the drug is relatively short, can be every 5 minutes to take a piece of sublingual. Isosorbide nitrate and nitroglycerin have similar adverse reactions, headache, dizziness, nausea, decreased blood pressure, tachycardia, etc. It is contraindicated for patients with allergy to drug components, glaucoma, elevated intracranial pressure, and hypotension. Isosorbide nitrate and nitroglycerin for the treatment of angina should be used under the guidance of a physician to choose the most appropriate drug for the patient.