Taking statin drugs will cause creatine kinase elevation, if you need to use for a long time, you should closely and dynamically monitor the liver and kidney function and creatine kinase values, and stop the drug in time if there is any problem. Statins have the effect of lowering blood lipids, anti-atherosclerosis, prevention of heart attack and cerebrovascular disease. The effect on muscle is one of the most common side effects of statins, which can cause muscle pain, and in severe cases, rhabdomyolysis, followed by elevated creatine kinase. If there is a suspected generalized weakness and muscle pain while taking statins, you should go to the hospital and have the creatine kinase value tested to determine whether statin-associated muscle damage has occurred, and when the creatine kinase exceeds five times the normal value, you need to stop taking the drug in a timely manner. Creatine kinase is an indicator of muscle damage, and elevated values are mainly seen in acute myocardial infarction, myocarditis, rhabdomyolysis and other conditions, in addition to undergoing thrombolytic therapy, surgery and other conditions will also be elevated. Strenuous exercise can also cause high creatine kinase, which usually does not require special treatment and will return to normal after a few days of rest. In addition, taking statins can also cause damage to liver and kidney function and the gastrointestinal tract, long-term use of drugs need to be closely monitored for adverse reactions, and problems in time to go to the hospital for further treatment.