Serpent Wrap, or shingles, is the result of infection with the varicella-zoster virus. Varicella-zoster virus initial infection of the human body, can occur chickenpox or hidden infection, part of the virus will be dormant in the posterior root ganglia of the spinal cord or cerebral nerve sensory ganglia, when the human body’s immunity is lowered or defective, the latent virus will be activated, along the sensory neurons to transfer to the innervation of the corresponding skin area, damage to the nerves, cause pain, and a large number of replication of the virus, causing a rash. Herpes zoster is a contagious skin disease with a clear source of infection, route of transmission, and susceptible population. The main source of infection is people with herpes zoster. Herpes zoster blister fluid contains a large number of infectious virus particles, so contact with herpes zoster patient blister fluid should be avoided. Women are generally more susceptible, and people over 50 years of age, who are subjected to stress or trauma, or infections; people who are stressed and fatigued; people with reduced immune function or immune disorders; people who are taking immunosuppressive drugs; people who are taking immunosuppressive drugs after organ transplantation; people who are undergoing chemotherapy; and people who have not been vaccinated against chickenpox are more susceptible to herpes zoster infection. Patients with shingles are advised to go to the hospital in time for active treatment under the guidance of a doctor, and not to treat the condition on their own to avoid the occurrence of postherpetic neuralgia.