The treatment of vascular leukoaraiosis syndrome has long been a challenge in the field of vascular surgery and rheumatology, and there is still controversy about whether to perform vascular stenting. It broke the traditional doubt that patients with vascular leukoaraiosis syndrome are not suitable for stent implantation and brought good news for patients with vascular leukoaraiosis syndrome. Patient xx, male, 50 years old, was admitted to the hospital in emergency because of “back and back pain for a week, aggravated by left lumbar and abdominal femoral pain for 4 days”. If the patient was not treated by emergency surgery, the pseudoaneurysm would further increase and rupture at any time would be life-threatening. After thorough discussion in the department, Director Zhou Dong decided to perform emergency surgery and performed abdominal aortic stenting and iliac artery stenting under local anesthesia, and the surgery was successful. After the operation, he was given hormone and immunosuppressive drugs. In February 2012, the patient came to our hospital for review, and CTA showed that the hematoma in the left lumbar region had been absorbed, and the stent was in a good position with no rupture, and now we continue to follow up. Patient xx, male, 31 years old, was admitted to the hospital with the main reason of “painful mass at the root of left thigh for more than 1 month, aggravated for half a month”, and had recurrent oral mucosa and external genital ulcers. The operation was successful. After long-term hormonal and immunosuppressive therapy, the patient was readmitted to the hospital in January 2012 for review. Whether endoluminal treatment is suitable for patients with vascular leukoaraiosis syndrome is still very controversial. For patients with vascular leukoaraiosis syndrome complicated by pseudoaneurysm, endoluminal intervention should be performed at an appropriate time based on active treatment of the primary disease, and long-term hormone and immunosuppressive therapy should be continued after the operation, so as to save the patients’ lives. After the successful treatment of two patients with vascular leukoaraiosis syndrome, our vascular surgery department has accumulated certain experience in the diagnosis and treatment of vascular leukoaraiosis syndrome, which brings good news to patients with vascular leukoaraiosis syndrome.