The traditional definition suggests that two years of formal drug therapy with no effect can be called drug-refractory epilepsy. Clinical studies have found that if the epilepsy is clearly typed and targeted medications are used, then the first medication can achieve a 40% effect. If this drug is ineffective, a combination of two drugs is needed, which may have a 20-30% effect. If a third drug is used, it is only 10% effective. It can be seen that the effect of drug control is poor with more than two drugs. Gu Shuo, Department of Neurosurgery, Shanghai Children’s Medical Center, therefore, for children with epilepsy, targeted medication after clear epilepsy typing, regular medication for 6 months, and the combination of two drugs is ineffective, it can be considered drug-refractory epilepsy.