Yellow nasal mucus and yellow sputum cough may be caused by acute upper respiratory tract infection or acute sinusitis and other diseases, and its treatment needs to be targeted according to different causes. 1. Acute upper respiratory tract infection: the main pathogens are viruses and a few are bacteria, which can be manifested as nasal congestion, runny nose, cough, fever and other symptoms. If there is a bacterial infection, there can be yellow nasal discharge, cough yellow sputum and other symptoms. Oral first-generation cephalosporins such as cefradine and macrolides such as azithromycin can be used according to epidemiologic history and experience. 2. Acute sinusitis: acute purulent sinusitis, the affected side of a large amount of mucopurulent or purulent nasal mucus, there is a sense of blowing away, or feel “phlegm” can only be inhaled back into the pharynx and then spit out, can be manifested as yellow nasal discharge, coughing up yellow sputum and other phenomena. It is advisable to preferred and adequate use of penicillin antibiotics such as amoxicillin, at the same time can be given 1% ephedrine saline drops to promote the ventilation of the sinuses. Yellow snot and yellow sputum can also be caused by other diseases, if the symptoms do not improve or aggravate, it is recommended to consult a doctor in a timely manner to determine the cause of the disease, and comply with the doctor’s instructions for treatment.