Thyroglobulin is generally located in thyroid cells and is a large glycoprotein complex synthesized by thyroid follicular epithelial cells. The thyroglobulin content in normal blood is relatively low. When the thyroid follicular wall is damaged, it can lead to a large amount of thyroglobulin being released into the blood, resulting in high thyroglobulin, which can be caused by benign thyroid disease, malignant thyroid disease, enlarged thyroid tissue, surgery, etc. 1. Benign thyroid disease: such as thyroiditis, Hashimoto’s thyroiditis, painless thyroiditis, postpartum Thyroid gland diseases: such as thyroiditis, Hashimoto’s thyroiditis, painless thyroiditis, postpartum thyroiditis, subacute thyroiditis, hyperthyroidism, goiter and many other benign thyroid diseases, due to the destruction of the thyroid follicular wall, can cause a large release of thyroglobulin, resulting in the manifestation of high thyroglobulin; 2. Malignant thyroid diseases: mainly refers to patients with thyroid tumors, after successful total thyroidectomy or radioactive iodine-131 treatment, basically If high thyroglobulin is detected, it mostly represents the presence of metastatic lesions of the tumor, resulting in a large amount of thyroglobulin release; 3. 4. Surgical factors: When partial thyroidectomy is performed, the thyroid follicular cells may be damaged, resulting in the release of large amounts of thyroglobulin, which is usually increased when thyroglobulin is measured after surgery. synthesize iodine, and more thyroglobulin is needed to achieve iodine supplementation. During the treatment period, you should pay attention to your diet and limit the intake of iodized salt. Take proper rest, avoid staying up all night, and carry out appropriate medication, radioactive iodine therapy or surgery for their primary disease.