Menstruation with large blood clots is similar to the leakage (excessive menstrual flow or dribbling) most of them are not normal, may be related to incomplete abortion, endocrine disorders, uterine fibroids, uterine adenomyosis or intrauterine device, etc., which can easily lead to anemia, and it is recommended to seek medical treatment according to the condition in a timely manner. 1. Incomplete abortion: It should be clarified whether there is pregnancy or not. Incomplete abortion may have a lot of bleeding, and it needs to consult a doctor in time to clarify the condition and then perform an emergency operation to remove the uterus. 2. Endocrine disorders: estrogen-progestin hormone secretion disorders may lead to increased menstrual flow, especially in the perimenopausal period, can follow the doctor’s instructions to carry out emergency diagnostic curettage or medication to stop bleeding, and endometrial biopsy, to exclude the causes of organic diseases, after the use of drospirenone ethinyl estradiol tablets, ethinyl estradiol cyclopropylgestrel tablets and other estrogen and progestogen drugs to adjust the menstruation, or intrauterine placement of levonorgestrel sustained-release system, and so on. 3. Uterine fibroids or adenomyosis: uterine fibroids or adenomyosis also often lead to excessive menstruation, and can be treated with gonadotropin-releasing hormone agonists as prescribed by the doctor to inhibit the progression of the fibroids or adenomyosis. If the disease continues to progress or the effect is unsatisfactory, and if anemia occurs, surgical treatment of the primary disease is usually required. 4. Intrauterine device: after placing the intrauterine device, especially the one containing progesterone drug, it may lead to irregular bleeding or too much bleeding, which can be treated with symptomatic treatment such as Yunnan Baiyao and tranexamic acid to stop bleeding, and the bleeding symptom may be relieved after a period of time to adapt to the situation, and the intrauterine device needs to be taken out if necessary. Heavy menstruation is related to many factors, it is recommended to consult the gynecology department of a regular hospital to identify the cause of the problem for further treatment.