The shedding time of cryo warts is related to the local blood circulation and whether the tissue is completely necrotic or not, so it can not be generalized. In clinical practice, warts are a common benign epidermal growth caused by human papillomavirus infection. The so-called freezing warts method, is the application of liquid nitrogen sprayed to the patient’s warts surface, so that the protruding in the skin surface of the superfluous organisms due to the extremely low temperature necrosis, and gradually dry, fall off. After the cryotherapy, whether the warts fall off and the length of time, and the local blood circulation, whether the tissue is completely necrotic. Some of them are not sufficiently frozen, so they are not necrotic and need to be treated again, so the time of shedding is not generalized. After freezing to remove warts, waiting for the shedding period, the patient must pay attention to keep the skin clean, dry, to avoid the occurrence of skin infection. If there is any abnormality, it is recommended to consult a doctor in time, under the guidance of the doctor to carry on the treatment.