Taking omeprazole daily for more than 20 years may have adverse effects such as gastrointestinal symptoms, bone fracture and anemia. Omeprazole mainly has the effect of inhibiting gastric acid, and it is generally well tolerated by most patients, but long-term administration of omeprazole by individual patients may also lead to side effects as follows: 1. Gastrointestinal symptoms: for example, nausea, vomiting, abdominal pain, constipation and other related symptoms may occur. Generally, this situation can be relieved by stopping the drug, if the adverse reactions continue after stopping the drug, it is recommended to consult a doctor in time. Long-term consumption of omeprazole, but also the formation of gastric fundus gland polyps. 2. Fracture: studies have shown that long-term use of proton pump inhibitors such as omeprazole can increase the risk of fracture in patients, the reason is related to the impact of calcium absorption, calcium and phosphorus metabolism. 3. Anemia: Omeprazole inhibits gastric acid secretion, but gastric acid can help the absorption of iron and vitamin B12, which are related to the occurrence of anemia. 4. Increased incidence of gastric tumors: some studies have shown that patients who have been taking omeprazole and other proton pump inhibitors for a long time have a tendency to increase the incidence of gastric tumors such as gastric cancer, which should be taken seriously. Taking omeprazole every day for more than 20 years there may also be many adverse reactions, so omeprazole needs to be used under the guidance of a doctor, in accordance with the doctor’s recommendation of the usage, dosage, and dosage regimen for the use of drugs, you can reduce the side effects to a certain extent.