Chronic inflammation of the mucosa with intestinalization refers to the findings of a gastroscopic biopsy and is a description of pathologic changes in the gastric mucosa. That is, there are chronic inflammatory changes in the gastric mucosa, such as hyperplasia and exudation, accompanied by the replacement of the gastric mucosal epithelium by the intestinal mucosal epithelium containing Paneth cells or cup cells. Chronic inflammation of gastric mucosa with intestinal metaplasia is mostly seen in chronic gastritis, especially atrophic gastritis, which is a kind of pre-cancerous lesion, i.e., there is a possibility of cancer, especially when the degree of intestinal metaplasia is high, but this process usually develops slowly, and it is recommended that gastroscopy be repeated regularly and biopsy be taken from the lesion tissue. For chronic inflammation of gastric mucosa with intestinal metaplasia, it is necessary to actively treat the primary disease and check whether there is Helicobacter pylori infection, and it is recommended to consult a doctor immediately to clarify the diagnosis and carry out targeted treatment.