Estrogen is mainly secreted through the ovaries. Estrogen is mainly secreted by the ovaries, and the adrenal glands can also secrete trace amounts of estrogen, which has a very important role in the endocrine, cardiovascular and metabolic effects. Estrogen production is mainly through ovarian secretion, and ovarian hormone secretion is regulated by the hypothalamus or pituitary gland hormone secretion. The body maintains a stable level of estrogen through neuroendocrine regulation. If estrogen production is insufficient due to various reasons, it can be regulated by medication under the guidance of a doctor, such as estradiol valerate and other medications.