Whether stage III colon cancer can be cured or not depends on the specific situation. If one can actively cooperate with the treatment and control the growth, development and spread of the tumor, the symptoms can be alleviated, life span can be prolonged, and the effect of cure can be achieved. Stage III colon cancer belongs to the progressive stage of colon cancer, the tumor is large, it may have invaded the muscularis propria or broken through the muscularis propria to reach the sub-plasma layer, or it may have invaded the plasma layer but not broken through the plasma membrane, and metastatic lymph nodes have already appeared around the tumor. Cancer tumors grow rapidly, and if they are not controlled, systemic metastasis will occur in serious cases, which may be life-threatening. Therefore, active treatment is the key, and the treatment method is mostly based on surgical resection, in addition to surgical treatment, radiotherapy, chemotherapy and targeted therapy can also be chosen. The specific treatment plan for stage III colon cancer needs to be determined by the doctor with the actual situation of the patient, and it is best to strive for the maximum eradication of the tumor, supplemented by chemotherapy to achieve the purpose of cure and prolong life.