The choice of cephalosporin or levofloxacin for patients with pyelonephritis needs to be based on the resistance spectrum of the bacteria being infected. Pyelonephritis is categorized into acute pyelonephritis and chronic pyelonephritis. Acute pyelonephritis or chronic pyelonephritis is mainly caused by bacterial infection, and the antibiotics should be chosen according to the resistance spectrum of bacteria. 1. Acute pyelonephritis: urine culture is needed before treatment, and before the culture result is available, empirical medication is needed according to the drug resistance spectrum of local bacteria, cephalosporins or quinolone antibiotics such as cefixime or levofloxacin can be chosen, and cephalosporins can be chosen in the case of a minor or a pregnant woman; the choice will be based on the results of drug sensitivity after the results of drug sensitivity. 2. Chronic pyelonephritis: if chronic pyelonephritis is non-acute exacerbation, there is no need to apply antibiotics for treatment, at this time, the main nephropathy integration treatment, need to lower blood pressure, control urinary protein, reduce creatinine and other treatments. The choice of drugs for the treatment of pyelonephritis needs to be determined by a specialist according to the patient’s symptoms and laboratory tests, and should not be self-selected.