Commonly used antidepressants with treatment for insomnia include agomelatine, mirtazapine, etc. Agomelatine, as a 5-hydroxytryptamine 2A receptor antagonist as well as a melatonin receptor agonist, can be a good mood reliever and has an important role in stress. Agomelatine can increase the release of norepinephrine as well as dopamine in the central nervous system by antagonizing 5-hydroxytryptamine receptors, and can also modulate melatonin receptors, which will have a significant effect within 1 week in patients with depression and insomnia. Mirtazapine as a tetracyclic antidepressant can have a significant sedative effect, which is very effective for patients with depression in terms of sedation, anti-anxiety and even improvement of insomnia, and can effectively improve the symptoms of insomnia, especially adjusting the structure of sleep.