Hypofractionated right maxillary sinus malignancy usually indicates that the cancer cells are less differentiated and relatively more malignant. The cause of the disease is unknown, and it may be accompanied by symptoms such as cheek bulge and eye discomfort, and should actively cooperate with doctor’s treatment. Hypofractionated right maxillary sinus malignant tumor mostly refers to the patient’s medical examination process, in which low differentiation degree of the lesion is found, and the tissue of the lesion has immature morphology, but the degree of malignancy is high and the cancer cells are easy to metastasize, and so on. The etiology of malignant tumor of right maxillary sinus is still unclear, which may be related to genetic factors, frequent exposure to carcinogenic substances, long-term inflammatory stimulation, air pollution and so on. Early symptoms of patients are not obvious, but with the progression of the disease, patients will have symptoms such as cheek bulge, eye discomfort, limited mouth opening and alveolar deformation. Surgical treatments such as total maxillary resection and cervical lymph node dissection are feasible for those with definitive disease, and can also be combined with radiation therapy, chemotherapy, targeted therapy, immunotherapy, etc., in order to control the progression of the disease and improve the prognosis. It is recommended that people with right maxillary sinus malignant tumor with low differentiation be evaluated by a doctor in order to develop an appropriate treatment plan so as to achieve the ideal therapeutic effect. Pay attention to the medication prescribed by the doctor, do not use drugs or prescriptions on your own.