P53 negative is a data result in the pathological examination results, usually means that the carcinoembryonic antigen is in the normal state, and can play the regular anti-tumor effect. p53, also known as oncoprotein antigen, is a factor that inhibits the growth of oncogenes in the body, and a negative result means that this indicator is in a normal state and can play a normal anti-tumor role. p53 is associated with common types of tumors in the clinic, for example, liver cancer, breast cancer and so on, and this factor has the function of helping the body to repair the defective genes, which can make the cancer cells commit suicide and prevent them from turning into cancerous cells. Therefore, p53 negative means that this indicator is normal, but it needs to be combined with other indicators to make a comprehensive judgment, and it is recommended to analyze under the guidance of a doctor.