Taking ibuprofen capsules for headache is effective and is generally indicated mainly for patients with mild headaches. If primary headache disorders are considered, such as patients with mild migraine, patients with mild headaches can take ibuprofen, indomethacin, naproxen, and also aspirin and acetaminophen, and additionally for patients with tension headaches. Ergotamine caffeine can be applied if the patient’s headache is severe, and also zolmitriptan and sumatriptan can be used for treatment. Ibuprofen can also be taken if the patient has a headache caused by gingivitis, otitis media or frontal sinusitis. Also ibuprofen can be taken if it is caused by fever or cold, and acetophen can also be taken. If the headache is severe, the patient should take pindostatin or prednisone, which may cause sleep disorder in severe cases. In addition, if the headache is caused by intracranial organic lesions, most of the patients may be caused by increased intracranial pressure, and the main treatment is to lower the cranial pressure, and the drugs include mannitol and glycerol fructose.