Calluses on the hands, also known as calluses, can be removed through temporary observation, drug intervention, physical therapy and other ways. 1. Temporary observation: because the callus has the role of protecting the organism, so generally do not need to be treated, through the reduction of friction can be relieved. 2. Pharmacological intervention: If the hands of the stratum corneum is too thick, you can also choose the way of drug intervention, such as the use of retinoic acid ointment, salicylic acid ointment and other keratolytic agents, can be soaked in the palm of the hand after the callus with the instrument will be flattened, and then coated with medication, which can play a role of chemical peeling, which is conducive to the removal of the callus. 3. Physical therapy: patients can use carbon dioxide laser or liquid nitrogen freezing, so that the callus parts of the skin necrosis and shedding, and then achieve the purpose of removing the callus palm. It is recommended that patients with calluses on the palm of the hand, according to their own situation, so as to give the corresponding treatment, medication and other treatments should be carried out under the guidance of a doctor.