Clinically, fine needle puncture is often required to clarify the nature of the lesion in nodules or masses suspected of thyroid malignancy. Generally speaking, the procedure of thyroid puncture has the following steps: i. The patient is placed in a flat position and the puncture area is routinely disinfected with sterile towels. The patient is instructed to hold his breath to avoid swallowing movements that may cause up and down movement of the thyroid gland and make it difficult to fix the puncture site. After satisfactory local skin infiltration anesthesia, a small 5-mm incision is made in the skin with a sharp knife. Third, the puncture needle slowly enters the thyroid lesion through the incision under the guidance of color ultrasound. IV. Six directions are usually selected for puncture and cytological smear. Local dressing pressure is applied for 6-8 hours after the puncture to prevent bleeding from the puncture site.