Pulmonary hypertension can lead to right heart failure and can be a stand-alone disease, a complication, or a syndrome. Pulmonary hypertension is a common and frequent disease with a high rate of disability and death, and should be given great attention. When pulmonary artery pressure is significantly elevated causing right atrial enlargement and right heart failure, the following signs may appear: significant jugular a-wave, enhanced pulsation in the pulmonary valve area, elevated pulsation in the right ventricle, systolic jet murmur in the pulmonary valve area, systolic regurgitant murmur in the tricuspid valve area, right ventricular 3rd and 4th heart sounds, jugular vein anger, liver enlargement, positive hepatic jugular venous reflux sign, lower limb edema, and Severe pulmonary hypertension, weak pulse and low blood pressure in those with reduced cardiac output. Early clinical symptoms of pulmonary hypertension are not typical and often misdiagnosed or missed. In order to obtain early diagnosis, we must closely combine clinical manifestations, signs and laboratory tests, and choose non-invasive or invasive examination methods according to different situations to firstly confirm the presence or absence of pulmonary hypertension, then determine its severity, and better yet, determine whether it is primary or secondary. 1.Be alert to early self-conscious symptoms Fatigue, exertional dyspnea and syncope cannot be considered as non-specific manifestations of chronic disease, it may be the better early manifestation of patients with pulmonary hypertension. 2.Special signs can suggest the cause such as sitting breathing, paroxysmal nocturnal dyspnea, wet bow pleural effusion at the base of the lung, suggesting that pulmonary hypertension is caused by postcapillary lesions, different heart murmurs can determine whether rheumatic valve disease or congenital heart disease is caused; body artery vascular murmur may be aortitis, pulmonary vascular murmur suggests that the blood flow through the narrowed pulmonary vessels, there may be thrombosis or pulmonary arteriovenous fistula in this area. The pulmonary vascular murmur may indicate pulmonary stenosis, which may be caused by thrombosis or pulmonary arteriovenous fistula. 3.Adequate use of non-invasive tests ECG, X-ray chest film, echocardiography can effectively diagnose pulmonary hypertension caused by certain cardiac lesions, pulmonary function measurement can help identify obstructive or restrictive lung disease, blood gas analysis can distinguish whether hypoxic pulmonary hypertension, radionuclide can show thromboembolic pulmonary hypertension in the lung segment and above. 4.Right heart catheterization Right heart catheterization is a better and reliable examination means, which can clarify the severity of pulmonary hypertension, with or without reversibility, and help to diagnose the etiology, such as elevated pulmonary capillary wedge pressure, which indicates post-capillary pulmonary hypertension, determination of blood oxygen content in different parts can reveal left-to-right shunt, and also can reveal thrombus, vascular malformation, dysplasia or stenosis by selective pulmonary arteriography. 5.Lung tissue biopsy (not recommended in general) As the early clinical symptoms of pulmonary hypertension are atypical, the etiology can be clarified by the above exclusion diagnostic methods, and if these diagnoses are still not confirmed, lung biopsy can be chosen for identification.