Numbness of the skin if localized may be due to physiological factors such as prolonged inactivity, or it may be caused by diseases such as multiple peripheral neuritis and diabetes. 1. Physiological factors: prolonged inactivity or maintaining a posture, resulting in poor blood circulation, temporary skin numbness, which is a normal phenomenon. 2. Multiple peripheral neuritis: it is a neurological disorder of movement and sensation of the distal limbs, which can be caused by infection, endocrine disorders, nutritional disorders, etc. Symmetrical hyperalgesia of the distal limbs may occur, which is distributed like a stocking stuffer, and the patients may have numbness of the skin. 3. Diabetes: diabetic patients with neuropathy will produce sensory abnormalities in the extremities, skin numbness, etiology and genetic and environmental factors, is a group of metabolic diseases characterized by a chronic increase in blood glucose levels. There are many reasons for skin numbness, after excluding physiological factors, it is recommended that patients seek timely medical attention to clarify the cause of the disease.