Fulminant liver failure is a syndrome of massive production of hepatocellular necrosis and severe hepatic impairment caused by multiple etiologies, with no previous history of liver disease and the onset of hepatic encephalopathy within 8 weeks of the disease. It has an acute onset, rapid progression and high mortality rate. Early diagnosis and early treatment can reduce the mortality rate. Early symptoms include jaundice, persistent hypothermia, low fever, gastrointestinal symptoms, bleeding tendency, progressive liver shrinkage, liver odor, fluttering tremor, accelerated heart rate, hypotension, etc. Late symptoms are manifested as hepatic encephalopathy, cerebral edema when there are ankle clonus, slowed breathing, irregular rhythm, coagulation dysfunction and bleeding bleeding sites to skin, gums, nasal mucosa, bulbar conjunctiva and gastric mucosa. FHF caused by hepatitis virus, drug poisoning, and muscarinic poisoning, its liver pathology is characterized by extensive hepatocyte necrosis, hepatocyte disappearance, and liver volume reduction. There is usually no hepatocyte regeneration, mostly collapsed reticular scaffolds, residual hepatocyte sludge, and inflammatory cell infiltration in the confluent area. Liver pathology in acute fatty liver and Reye syndrome during pregnancy is characterized by severe damage to mitochondria within the hepatocytes, which leads to metabolic malfunction. The hepatic lobules to middle band cells are enlarged and the cytoplasm is filled with fat vacuoles in a honeycomb pattern without large hepatocyte necrosis. Liver shrinkage is less dramatic than in acute severe hepatitis. What are the causes of progressive hepatic shrinkage? Fulminant Hepatitis Like Syndrome: A group of non-viral hepatitis syndromes whose pathogenesis is not well understood and which have fulminant hepatitis-like manifestations. These include acute fatty liver in pregnancy, tetracycline-induced toxic hepatitis and Reye’s syndrome, but if cured, the liver can be completely restored to normal. The symptoms of this group include acute onset, severe nausea, vomiting and abdominal distention, bleeding tendency, and impaired consciousness. Fulminant hepatic failure (FHF): A syndrome in which the patient has no liver disease but suddenly develops massive hepatocellular necrosis or significant abnormalities in liver function, and hepaticenc ephalopathy (HE) occurs within 8 weeks after the first symptoms. The etiology of fulminant liver failure is diverse and can be classified as infectious, toxic, metabolic, infiltrative, autoimmune, ischemic, radiation-invasive and of unknown origin depending on the etiology. Viral hepatitis in pregnancy: it is a common infectious disease in obstetrics and has a greater impact on both mother and child, and is receiving increasing attention, especially in recent years, the progress of research on viral hepatitis at home and abroad has become more advanced, so that the impact of the disease on mother and child, such as vertical transmission from mother to child, maternal and infant mortality and breastfeeding, etc., has received more attention. The incidence of combined viral hepatitis in pregnancy is approximately 0.025% to 0.080%, with a higher incidence in late pregnancy.