The need for treatment of hepatitis B minor tri-positive is determined by the presence or absence of symptoms and the results of relevant tests: when the examination reveals that it is hepatitis B minor tri-positive, the first thing to do is to go to the hospital for a comprehensive examination, which must include hepatitis B virus, DNA quantification, liver function, and liver, gallbladder and spleen ultrasound. If the liver function is abnormal or the liver, gallbladder and spleen ultrasound reveals that the liver disease has progressed or there is already cirrhosis, it is necessary to carry out antiviral treatment. In addition, for a patient with small triplet hepatitis B who has a family history of cirrhosis or liver cancer, the application of antiviral drugs is highly recommended, even if there are no obvious abnormalities in liver function and hepatobiliary and splenic ultrasound. A part of patients with small triplet hepatitis B have good liver function, liver ultrasound of liver, gallbladder and spleen reveals good morphology and density, etc., and liver elasticity examination is normal, it is possible not to carry out antiviral treatment, but close follow-up is necessary, once liver disease is found to have progressed, it is still necessary to carry out antiviral treatment.