There are a wide variety of antibacterial solutions on the market, not all of them are effective for grey nails and need to be analyzed according to their composition. Even if it is an effective antibacterial solution, it only has an auxiliary therapeutic effect to a certain extent. It is not clinically recommended to apply the drug for the treatment of grey nails, and it is recommended to apply antifungal medication. Most antibacterial solutions are only effective against bacterial infections, such as those containing tetracycline, erythromycin and other ingredients. In contrast, gray nails are a disease caused by fungal infection of the nail plate or under the nail, so antibacterial infection ingredients are not effective for gray nails. A few anti-bacterial solutions include deacetyl chitosan, salicylic acid, and the Chinese medicine dahurica, which are effective in treating gray nails and can inhibit fungal growth to some extent and help soften and remove diseased nails. However, patients need to be clear that due to the thickening of the nail plate, the anti-fungal solution cannot effectively penetrate and achieve the effect of killing the fungus, so the anti-fungal solution can only play a supplementary therapeutic role. The clinical application of antifungal drugs, such as oral fluconazole, itraconazole, terbinafine, and topical drugs such as salicylic acid and amorolfine nail coating, are mostly used for gray nails. If the medication is not effective, or if the nail bed and nail separation symptoms have appeared, it is recommended to go to the hospital in time for nail extraction surgery. The patient should not use drugs such as antibacterial solution without permission, but usually need a combination of medications to treat the nail, and a standardized and full course of treatment to get a better improvement.