Pimples are usually referred to as acne, a chronic inflammatory skin disease of the sebaceous glandular units of hair follicles. Hydrogen peroxide should not be rubbed on the face for acne. Hydrogen peroxide has antibacterial and antiseptic effects, but it also has a certain degree of irritation and corrosive, if not used properly may cause redness, dryness and flaking of the facial skin, but aggravate the symptoms of acne. Acne patients should be treated with topical medication (e.g., retinoids, benzoyl peroxide, etc.), oral medication (e.g., retinoids, antibiotics, etc.), physical therapy (e.g., red and blue light irradiation, photodynamic therapy, etc.), or chemotherapy (e.g., if acid peeling, etc.), etc., according to the severity of their condition under the direction of their doctors. In addition, acne patients need to use mild cleansers to avoid damaging the skin barrier function and aggravating acne. Therefore, hydrogen peroxide, which is irritating and corrosive, should not be used to rub acne on the face. It is recommended that acne patients go to a regular hospital in a timely manner, to clarify the severity of the condition and follow the doctor’s instructions to standardize the treatment, avoid self-medication or listen to prescriptions, so as to avoid delaying the condition and causing serious adverse reactions.