Closed-cell acne is the acne manifestation of acne, which is caused by exuberant sebum secretion and abnormal keratinization of hair follicles and poor drainage, and can be treated with topical medications, chemical peels, and needle clearing. 1. Topical medication: Vitamin A acid cream and Adapalene gel, with a common concentration of 0.1% and 0.3%, can dissolve microcomedones, and should be avoided due to its photosensitivity. 2. Chemical peeling: commonly used azelaic acid, amygdalic acid, salicylic acid, etc., can promote epidermal exfoliation and dissolution of acne, the treatment is generally 2 to 4 weeks once. 3. Needle clearing: use sterilized acne needles, physical extrusion to discharge acne, need to be sterilized by a professional physician. The above treatment should be carried out under the guidance of a physician, and the medication should be administered according to the doctor’s instructions, and should not be self-medicated.