Higher myoglobin does not cause higher transaminases, but if both are elevated, it is necessary to seek medical attention to determine whether the injury is to the skeletal or cardiac muscle, and then to treat the cause of the injury, e.g., myocardial infarction may require interventional placement of a stent or thrombolytic treatment with urokinase, and skeletal muscle lysis may require rehydration of fluids and alkalinization of the urine. Myoglobin and aminotransferases are both found in the rhabdomyolysis muscle and are mainly seen in cardiac or skeletal muscle injuries. If both are elevated, it is important to seek medical attention to determine which type of rhabdomyolysis is present. Muscle pain is often indicative of skeletal muscle injury, and chest pain or changes on the electrocardiogram are often indicative of cardiac muscle injury. In the case of myocardial injury, it is commonly associated with infarction or myocarditis. The former may require emergency placement of a coronary stent or urokinase lysis, while the latter requires antiviral therapy and attention to nutritional support and rest. In addition, coronary artery disease may also cause mild elevation of these markers, usually requiring oral aspirin and other medications. In case of skeletal muscle injury, which is commonly caused by over-exercise, drug injury, etc., it is necessary to remove the above causes in time; in addition, it is necessary to replenish fluids, use sodium bicarbonate and other drugs to alkalize the urine, to avoid kidney damage. In conclusion, elevated myoglobin and aminotransferases require prompt medical attention.