Urticaria on the hands need to find the triggering cause and avoid, on this basis, also need to follow the doctor’s advice oral (such as loratadine, diclofenac tadine, etc.) or topical application of drugs (such as glycerine lotion, etc.). 1. Finding the triggering cause: urticaria on the hands is mostly caused by the body’s ingestion, inhalation, and contact with allergens. Therefore, it is necessary to actively search for allergens (e.g., fish, shrimp, mango, dust, dust mite, and sunlight, etc.) and avoid them, and if you suspect that the allergens are medications (e.g., penicillin, vaccines, etc.), you need to change the medications as instructed by your doctor and replace them with other medications. 2. Oral medication: (1) acute urticaria: after removing the cause of the disease, it is necessary to comply with the medical advice of oral antihistamine drugs, such as loratadine, cetirizine, avastin, etc., the more serious or with laryngeal edema, oral prednisone, etc., to control the condition. Critically ill patients may also require tracheotomy. (2) Chronic urticaria: Patients with chronic urticaria should first choose antihistamines, such as dicloxacillin, ebastine, etc. If the symptoms cannot be relieved by antihistamines alone, cimetidine, montelukast, etc. can be used in combination to improve the symptoms. Antihistamine drug treatment is ineffective, can also use immunosuppressants, such as cyclosporine, tacrolimus, etc. If the above treatment is ineffective, can also use glucocorticoids. 3. Local medication: patients can also use local glycerine lotion, halomethasone cream, etc., to reduce discomfort. It is recommended that patients go to the hospital in a timely manner, under the guidance of the doctor, standardized treatment, avoid scratching the affected area, so as not to cause infection.