Glutathione reductase assay can be used to assist in the diagnosis or exclusion of liver diseases such as acute hepatitis, drug-induced liver injury, toxic hepatitis, and chronic hepatitis. Glutathione reductase is very important in protecting the integrity of hepatocyte membranes, and therefore assists in the diagnosis of liver disease. Of course, elevated glutathione reductase can also be caused by physiological reasons, such as strenuous exercise, meals, alcohol consumption and other factors. Among them, primary hepatocellular carcinoma, extensive metastatic liver tumors, acute viral hepatitis and other diseases will lead to a significant increase in serum glutathione reductase. This is because of the rapid progression of the disease mentioned above and the obvious destruction of hepatocytes, which leads to a large amount of glutathione reductase being released into the bloodstream, and thus serum glutathione reductase is significantly elevated; In the early stage of cirrhosis, due to individual differences in the degree of destruction of hepatocytes, the enzyme will be increased to different degrees. Therefore, when glutathione reductase index is abnormal, it should be combined with other indexes and clinical symptoms to determine the condition of the patient, and it is necessary to consult the doctor in time and do not take medication without authorization.