Gliclazide tablets and metformin can be taken together. Gliclazide tablets belong to sulfonylurea hypoglycemic drugs, metformin belongs to biguanide hypoglycemic drugs, both can be used in diabetic patients. Generally, gliclazide tablets and metformin can be taken together without drug-drug interactions. Gliclazide tablets may cause hypoglycemia, vomiting, epigastric pain, and constipation and other adverse reactions, and is contraindicated in people who are allergic to this drug. Metformin may cause diarrhea, nausea and vomiting and other adverse reactions, type 2 diabetes mellitus combined with acute severe metabolic disorders, severe infections, hypoxia and other conditions prohibit the use. Patients should take the above two drugs under the guidance of a doctor to avoid adverse reactions.