TB Hirschsprung’s-like reaction usually lasts two to three weeks, but there is wide individual variation. Hirschsprung’s reaction refers to the use of powerful anti-tuberculosis drugs (e.g. isoniazid, etc.) in anti-tuberculosis treatment, causing a large number of tuberculosis bacilli to die within a short period of time, and the cellular debris of their death lysis produces a huge stimulus to the immune system, which triggers an even stronger immune system response, which is a kind of hypersensitivity, such as a change from a low-fever to a high-fever, a more severe cough, and an increase in the number of peripheral leukocytes in an examination. etc. Generally, after two to three weeks of anti-tuberculosis treatment, these phenomena will disappear quickly and are generally not harmful to the body. However, due to individual differences, the duration varies greatly, with some young people experiencing it for only four or five days, but others for more than a month.