If the yellow color of sperm is caused by a long period of non-ejaculation, generally no medication is needed; and for the yellow sperm caused by inflammatory reactions, oral cephalosporin antibiotics, quinolone antibiotics, macrolide antibiotics, etc. are needed. If it is only due to a long time without ejaculation, resulting in yellow sperm color, is a normal reaction, usually no need to take medication, temporary observation can be. If the yellow color of sperm is caused by prostatitis, seminal vesiculitis, orchitis, epididymitis and other diseases, you can take oral cephalosporin antibiotics, such as ceftriaxone sodium, ceftazidime, etc.; quinolone antibiotics, such as levofloxacin, ofloxacin, etc.; macrolide antibiotics, such as azithromycin, clarithromycin, etc.. The appearance of yellow sperm color is recommended to timely visit the urology department, and then through the blood routine, semen routine examination, to understand the cause of the disease and then treatment, the above several drugs should be taken in accordance with the doctor’s instructions.