[Abstract] Background and Objective Intra-arterial embolization chemotherapy, argon helium knife targeted freezing and radiotherapy particle implantation are the main minimally invasive techniques for the treatment of lung cancer. This paper aims to explore the clinical efficacy of combining multiple minimally invasive treatment techniques for advanced non-small cell lung cancer by summarizing the quality of survival, clinical efficiency and survival of patients after treatment and analyzing the advantages and limitations of each technique itself. Materials and methods Retrospective analysis of 139 patients with pathologically confirmed and completed follow-up from July 2006 to July 2009, all of whom were lost to surgical resection on comprehensive evaluation. Among them, 102 were primary lesions and 37 were mediastinal, intrapulmonary and chest wall metastases. The combination of Ar-He knife targeted cryotherapy with radiotherapy and chemotherapy particle implantation treated 20 blood-depleted tumors. The KPS scores, imaging data and follow-up results of patients before and after treatment were compared and analyzed. The mean improvement of KPS score after treatment was 20.01. At 3 years of follow-up, there were 44 cases of CR, 87 cases of PR, 3 cases of NC, and 5 cases of PD, with an effective rate of 94.2%. 99 cases (71.2%) survived for 1 year, 43 cases (30.2%) survived for 2 years, and 4 cases survived for more than 3 years, with a median survival of 19 months. The mean survival was 16±1.5 months. There were no serious complications such as spinal cord injury, vascular and pericardial puncture injury. Conclusion Minimally invasive techniques operate with high success rate, minimal trauma, mild complications, and positive efficacy. In the case of primary non-small cell lung cancer, the combination of different minimally invasive techniques implemented in a targeted manner according to the patient’s specific conditions, complementing and synergizing each other, will further improve the medium- and long-term clinical outcomes of patients.