When the stomach is empty, it hurts to consider that it may be related to duodenal ulcer, gastritis and other diseases. 1. duodenal ulcer: duodenal ulcer refers to the duodenum in the gastric acid, pepsin and other digestive juices under the attack, its own mucous membrane damage to the formation of localized inflammatory defects, ulcers mainly in the duodenal bulb, with periodic epigastric pain as the main clinical symptom, which can be manifested as the stomach is empty on pain. 2. Gastritis: Gastritis usually refers to the inflammatory lesions of the mucosa of the stomach due to various reasons, the gastric mucosa is stimulated by pain, nausea and vomiting and other symptoms, when the stomach is empty, due to gastric acid and other stimuli can aggravate the pain in the stomach. There may be other reasons for the pain when the stomach is empty, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.