Pain is the prominent manifestation of bone metastasis of gastric cancer, and the painful site is the corresponding site of bone metastasis. Because bone metastasis of gastric cancer is multi-site metastasis, the pain site can be multiple sites, usually manifesting as severe pain that is unbearable, which can appear as pressure pain in the corresponding site, or pathological fracture in the corresponding site, which can be diagnosed by X-ray. If bone metastasis occurs in the spine, nerve compression symptoms, such as back and leg pain or paraplegia, can appear. Because bone metastasis of gastric cancer occurs in advanced stage, there are mostly clinical manifestations of advanced gastric cancer when bone metastasis occurs, such as weakness, loss of appetite, gastrointestinal bleeding, ascites, etc.