Cranial repair is now a relatively routine procedure in neurosurgery, and the surgical technique has matured considerably. At present, the most important factor affecting the effect of surgery is the choice of repair material. Some patients with cranial defects ask whether it is better to use titanium alloy or simulation for cranial repair. For this question, it is certain that titanium alloy is not the most ideal material for cranial bone repair at present. There is a new type of bionic skull material called polyetheretherketone, which is superior to titanium alloy material in all aspects. Titanium alloy for cranial bone repair, there may be the following drawbacks: first of all, it is a metal material, heat conduction effect is very strong, high temperature is easy to head tissue burns, at the same time may also have a sensitive reaction to the cold environment; in addition, this metal material will interfere with the patient’s postoperative CT MRI and other medical examinations, imaging artifacts, affecting the doctor’s judgment of the condition; titanium alloy biocompatibility is not ideal, and sometimes have rejection reactions occur. The biocompatibility of titanium alloy is not ideal, when there is a rejection reaction occurs ….. There are many problems with titanium alloy cranial bones, to name a few! It is because of these drawbacks of titanium alloy that Cao Mou, a patient with cranial defects from Shanxi, did not receive titanium alloy repair locally, but traveled all the way to Beijing to receive polyether ether ketone (PEEK) cranial bone repair, and the result of the repair was very satisfactory. This advanced PEEK material overcame the shortcomings of titanium alloy and became the latest trend in cranial bone repair materials.