If the average volume of red blood cells is high for simple red blood cell volume is high, generally no treatment is needed, if due to megaloblastic anemia and myelodysplastic syndromes and other disease factors, according to different causes of its treatment methods are different, as follows: 1. Simple high red blood cell volume: the normal range of average red blood cell volume is 80-100fl, and high volume can be seen in normal people. If the volume of red blood cell is simply high, and other test results (hemoglobin level, total number of red blood cells, platelet count, etc.) are not abnormal, then there is no need for treatment, and only need to recheck the routine blood test regularly. 2. Megaloblastic anemia: medications such as folic acid and vitamin B12 can be taken under the guidance of a physician. 3. Myelodysplastic syndromes: medications such as cytarabine and thalidomide can be taken under the guidance of physician; if the effect of medication is not obvious, hematopoietic stem cell transplantation can be performed. If the average volume of red blood cells is found to be high, it is recommended to go to the hospital, consult a specialist, improve further examination (such as bone marrow cytology examination, bone marrow biopsy, etc.) to clarify the diagnosis and targeted treatment.