Syphilis is divided into three stages, and the three stages are determined by the time of the disease. Stage I syphilis, also known as hard chancre or primary sore, which appears 2 to 4 weeks after sexual intercourse with a patient with syphilis. The nodules are hard to the touch and may have vesicles on the surface without pain. In the first 1 to 2 weeks after the appearance of the chancre, the lymph nodes on the same side are enlarged. At this time, the syphilis spirochete, the causative organism, is present in large quantities on the first sore and has not yet entered the bloodstream, so the serum syphilis spirochete test is negative at this time. About 4 weeks after sexual contact, syphilis spirochetes start to appear in the blood, and the test is positive at this time, which is called stage II syphilis. The skin manifestation of second-stage syphilis is the appearance of dark red, ranging from 1 to 3 cm in diameter, with a flaky, non-itchy surface, like pityriasis rosea, on the chest, abdomen, back, extremities, palms and soles of the feet, and if it appears on the palms is a characteristic of this stage and has a high diagnostic value. Stage II syphilis rash hair loss. Stage II syphilis rash occurs in the anus or vulva of women is a grayish-white flat wart-like material called flat warts. Stage I and Stage II together are called early syphilis. After 2 years of onset, it enters Stage III syphilis, also called late syphilis, which has dendritic swelling and damage to the heart and nervous system.