It accounts for —-1.3% to —-1.8% of intracranial tumors and 3% to —-12% of neuroepithelial tumors. It is more common in males than females, and it is common in middle-aged people. The peak of incidence is 30-40 years old. The majority of tumors are located in the supratentorial area, with the frontal lobe being the most common, followed by the parietal and temporal lobes. [The tumors are mostly located in the white matter, but can be seen in the cortex. The tumors are grayish-red in appearance, soft in texture, and the infiltration range is often extensive, and can protrude into the ventricles and cortical surface. The boundary between the tumor and brain tissue is clear, and sometimes pseudo-envelope can be seen. Some of the tumors may become jelly-like material. Microscopically, the tumor cells are abundant, uniform in shape, with round nuclei and deep staining; the brain pulp is less translucent or eosinophilic. The cells were arranged in cords or sheets. There was abundant vascularity with intimal hyperplasia and surrounding connective tissue hyperplasia. Malignant oligodendrocyte fields have a more rounded shape, larger and lighter-stained nuclei, more cytoplasm, and more common nuclear schizophrenia. Individual hepatic crippled cells are seen to disseminate with the cerebrospinal fluid. [Clinical manifestations] Most of the major glioblastomas grow slowly and have a long course, with an average of 2-3 years from the onset of symptoms to the time of consultation. Robert et al. reported a disease duration of 2.4-4.—-1 years, with the longest being 3.—-1 years. Epilepsy is the most common symptom of this disease, accounting for about 52%-79% of the cases. It is the most common among neuroepithelial tumors and often takes epilepsy as the first symptom, and some patients are mistaken as primary epilepsy and treated for many years, and the tumor is not found until the symptoms of increased intracranial pressure appear. Psychiatric symptoms are common in patients with frontal lobe major glioblastoma, especially those with extensive infiltration and expansion along the corpus callosum to the contralateral frontal lobe, who mostly show psychiatric symptoms, mainly emotional abnormalities and dementia. In addition to headache and vomiting, visual impairment and optic nerve papilloedema account for about l/3 of patients. tumor invasion of motor and sensory areas may produce hemiparesis, hemianesthesia and motor or sensory aphasia accordingly. [MRI scan shows low signal in Tl-weighted image and high signal in T2-weighted image, and the surrounding edema is easily distinguished from the tumor. If the tumor has large calcification, MRI shows a low signal area. Contrast enhancement is more prominent in oligodendroglial cell tumors after injection. Oligodendrogliomas without significant calcification need to be differentiated from astrocytomas; tumors with calcification need to be differentiated from arteriovenous malformations, which generally often show no peripheral edema and calcification, and abnormal vascularity and iron-containing yellow case deposits often coexist. Tumor calcification is mostly seen in the central part of the lesion, with indistinct boundaries and low signal; abnormal vessels may be bifurcated, tubular or dotted with low signal on T—-1 weighted images and proton density weighted images, and high signal on T2-weighted even echo images, which can be directly shown on gradient-echo weighted images. Enhanced MRI scan with intravenous Gd-DTPA can help to identify the difference. [Treatment and prognosis] Treatment is based on surgical resection, and the principle of surgery is to remove as much tumor as possible. The more complete the tumor resection, the lower the surgical mortality rate has been reported. If the tumor is confined to one frontal lobe, frontal lobe or occipital lobe, surgical resection is the more ideal treatment. Those with more complete resection often have a better outcome after surgery. An average survival of —-13 years has been reported, with individual reports of up to 40 years. The average survival after partial resection only (including biopsy and decompression) is 3.3 years. Such patients can be operated again to prolong their lives. Postoperative radiotherapy is effective, with 5-year and —-10-year survival rates of 52% and 32%.