The most common pathological type of nephrotic syndrome caused by hepatitis B is membranous nephropathy caused by hepatitis B virus and the deposition of immune complexes in the glomerular basement membrane causing kidney damage. Its treatment requires antiviral therapy and oral ACEI or ARB drugs to reduce urinary protein. The commonly used antiviral drug is entecavir; ACEI or ARB drugs, such as Irbesartan or Valsartan, Benazepril, etc. can be chosen. With these drugs for more than six months, if the nephrotic syndrome does not remit, hormonal as well as immunosuppressive therapy needs to be added to the antiviral regimen. The more commonly used regimen is entecavir combined with small doses of hormones and tacrolimus for these three drugs. In addition to these medications, the diet must be low in salt, low in fat, high in quality and low in protein. At the same time, the hepatitis B virus DNA, urine protein quantification, kidney function and other related indicators should be reviewed regularly at the hospital.