Sore and weak legs in dialysis patients may be caused by dietary inattention, osteoporosis, peripheral neurogenic damage of the lower limbs, electrolyte metabolism disorders, and carnitine deficiency due to dialysis. 1. Dietary inattention: If dialysis patients don’t pay attention to diet, it may lead to hyperkalemia, hypernatremia and so on. As dialysis proceeds, there is a definite decrease in blood sodium and blood potassium, at this time, it will cause the patient to suffer from leg soreness and lack of energy. 2. Osteoporosis: If dialysis patients are on long-term dialysis, it may lead to bone calcium loss and osteoporosis, causing symptoms such as leg soreness, lack of energy and joint pain. 3. Peripheral neurogenic damage of lower limbs: peripheral neurogenic damage of lower limbs is one of the common complications of dialysis, which is mainly manifested as soreness, weakness, numbness and sensory dysfunction of legs. 4. Electrolyte metabolism disorder: dialysis patients may lead to electrolyte metabolism disorder, such as low calcium, low potassium and so on, which cause symptoms such as leg soreness, lack of energy, generalized weakness and so on. 5. Carnitine deficiency due to dialysis: Carnitine deficiency due to dialysis is also an important cause of leg soreness and weakness in dialysis patients. When dialysis patients have sore legs and lack of energy, they should go to the hospital immediately for consultation, and follow the doctor’s instruction after clarifying the cause of the disease, so as to avoid delaying the condition.