Some patients with myasthenia gravis may require epidural anesthesia during their lifetime for reasons such as cesarean section, uterine fibroids, and lower extremity surgery, and many patients come to the clinic to ask questions about this. Some surgeons and patients “lose their color” when they hear about myasthenia gravis, fearing that anesthesia will aggravate the condition and cause critical symptoms, making it difficult to seek medical treatment for myasthenia gravis due to surgical problems. The epidural block anesthesia is the injection of local anesthetic into the epidural cavity, blocking the spinal nerve roots and temporarily paralyzing their innervated areas, called epidural interval block anesthesia, or epidural block for short. The local anesthetic drug is usually lidocaine, bupivacaine, etc. and mixed with epinephrine, which mainly acts in the subarachnoid space and does not directly affect the transmission of the neuromuscular junction. In the past, it was thought that epidural anesthesia might affect the patient’s respiratory function and put the patient at an increased risk of respiratory failure after surgery. However, subsequent studies have shown that this is not the case, and patients with myasthenia gravis have had great success with the use of epidural anesthesia in labor and delivery. Epidurals not only reduce the use of other anesthetic drugs during surgery, but also reduce the use of opioids postoperatively. Therefore, if a patient with myasthenia gravis requires epidural anesthesia for his or her condition, there is no need to look ahead and explain to the patient from a professional perspective to ease the psychological burden on the patient and family. At the same time, the concept of “epidural anesthesia is safer” needs to be conveyed to surgical colleagues, so that the patient’s related surgery can be performed smoothly and in a timely manner.