” Premature ejaculation is premature ejaculation impotence is impotence”. Premature ejaculation and impotence are first and foremost different from each other by name. Impotence, or erectile dysfunction (ED), refers to a man’s persistent inability to achieve or maintain an erection of sufficient hardness to complete satisfactory sexual intercourse under sexual stimulation. In other words, the key word for impotence is erectile hardness. Premature ejaculation (PE), or ejaculatory control disorder, although there is no global definition, all definitions of premature ejaculation include poor ejaculatory control, short ejaculatory latency and negative emotions (distress) due to premature ejaculation, and ejaculatory control is the key factor among these three. The key word for premature ejaculation is ejaculatory control. The etiology of PE and ED are different, and PE and ED are not the same disease.3 The clinical manifestations and effects of PE and ED are different. The common elements defined by PE are poor ejaculatory control; short ejaculatory latency; and low sexual satisfaction. men with ED are consistently unable to achieve or maintain an erection of sufficient hardness to complete satisfactory sexual intercourse under sexual stimulation. So, PE and ED are diagnosed differently, so it stands to reason that the preferred medications for PE and ED are different. Among the many prescription drugs currently used to treat PE, only dapoxetine hydrochloride (Bilirubicin) is approved for marketing in 60 countries for the treatment of premature ejaculation.