Infant sleep grunting and twisting can be seen in physiological phenomena and pathological conditions, the latter need to consult a doctor in time, symptomatic treatment, such as vitamin D deficiency need to supplement vitamin D; digestive tract diseases can be given probiotic treatment. 1. Physiological phenomenon: if the baby is in the teething period, when the emergence of milk teeth, the above performance, is a normal phenomenon, no need for special intervention, but need to monitor the growth of milk teeth, if necessary, stomatology consultation, or in the indoor environment with high temperature, the baby’s discomfort is obvious, sleep grunting and twisting, need to adjust the indoor temperature. In the infant sleep process, part of the grunting and twisting, no other symptoms of discomfort, such as fever, vomiting, etc., can be considered a normal physiological phenomenon, no special intervention, close observation can be. 2. Pathological conditions: such as vitamin D deficiency, such infants can appear to sleep uneasily, manifested in the above performance, some infants may also appear to be easily annoyed, shaking their heads, etc., and some of them may be accompanied by cranial softening, etc., and need to be appropriate sun exposure, vitamin D supplementation. In some digestive diseases, such as gastrointestinal dysfunction, abdominal discomfort, combined with the above manifestations, need to pay attention to the rational arrangement of diet, if necessary, oral microecological agents (such as Clostridium typhimurium live bacterial powder) and so on. The above medications should be used under the guidance of a physician, and it is recommended to actively seek medical advice and intervention from a specialized physician.