The discomfort symptoms of breast cancer are mainly manifested in the breast area, as follows: 1. skin changes of breast: such as sunken skin or orange peel-like changes, and the changes are related to the size and location of the lump, such as superficial and smaller lumps appearing skin changes in the early stage, while deeper and larger lumps are not easy to find skin changes; 2. breast lumps: common in the outer upper quadrant, mostly painless lumps; 3. nipple changes: such as asymmetric nipples on both sides or sunken nipples; 4. nipple overflow: mostly bloody, celiac or white overflow; 5. breast shape changes: such as one high and one low breast on both sides.