Reflux esophagitis may cause chest tightness, but is less common. Reflux esophagitis is a breakdown of the esophageal mucosa due to acid (alkali) reflux caused by a decrease in the anti-reflux function of the esophagus, a weakening of the defense barrier function of the esophageal mucosa, and delayed gastric emptying. Endoscopy may show redness, erosion, edema, congestion, and even bleeding of the esophageal mucosa. Patients with reflux esophagitis may experience reflux, heartburn, chest pain, epigastric pain, burning sensation in the epigastrium, belching, and other symptoms, as well as nausea, vomiting, bloating, and loss of appetite. If the acid (alkali) refluxes into the trachea, it may cause the patient to develop asthma or interstitial pneumonitis with chronic coughing, which in turn leads to symptoms such as chest tightness, shortness of breath, and dyspnea. Therefore, patients with reflux esophagitis may experience chest tightness, but it is less common. It is recommended to seek timely medical treatment for chest tightness symptoms, and to clarify the cause of the disease under the guidance of a professional physician to avoid delaying the condition.