1.Menthol insulin Drug composition: Using brewer’s yeast genus, the proline at the 28th position of the B chain of human insulin is replaced by aspartic acid, which prevents the self-aggregation of insulin monomer or dimer by using the repulsive effect of electric charge, so that it can be absorbed rapidly.
Indications: For the treatment of diabetes mellitus.
Contraindications: It is strictly prohibited during hypoglycemic episodes. It is contraindicated for those who are allergic to menthol insulin or any of the ingredients in this product.
Representative: Novolac 2. Lysergic insulin Drug composition: The order of proline and lysine at B28 and B29 of human insulin is switched, which reduces the non-polar contact between monomers in the dimer, so that the spontaneous polymerization property of insulin is changed and thus it is easy to dissociate.
Indications: It is indicated for the treatment of adult diabetic patients who require insulin to maintain normal glucose homeostasis.
Contraindications: The use of lysergic insulin is strictly prohibited during hypoglycemic episodes. It is strictly forbidden to use if you are allergic to lysergic insulin or its excipients.
Representative: Eugenol 3. Dietary insulin Drug composition: Dietary insulin has a C14 free fatty acid attached to the 29th position of the B chain, while the amino acid at the B30 position is removed. It is a clarified solution, and the molecule exists in the form of hexamer, but it can reversibly bind with circulating albumin, thus further prolonging the duration of action.
Representative: Novartis 4. Glycine insulin Drug composition: The intermolecular interaction is changed by replacing the 21-position menadione of insulin A chain with glycine and adding two arginines at the end of B chain.
Representative: Lysine