Perianal abscess is caused by inflammation and infection, usually gram-negative bacillus infection, so the choice of drugs to antibiotics. Antibiotics can choose the second generation of cephalosporins, favoring the treatment of gram-negative bacilli, commonly used representative drug is cefuroxime tablets; aminoglycoside antibiotics, representative drug is gentamicin; quinolone antibiotics, representative drug is norfloxacin capsules and levofloxacin tablets, etc., the effect of the infection of perianal abscess is relatively good. At the same time, it is also necessary to cooperate with Chinese patent medicine to activate blood circulation and eliminate blood stasis, which is more conducive to swelling. Proprietary Chinese medicines can choose to locust angle pill, Mai Zhi Ling capsule and so on. The specific use of drugs also need to be combined with the severity of the disease, by the physician to guide the use of drugs.