Diffuse large b-cell lymphoma is correctly referred to as diffuse large b-cell lymphoma, fever can be reduced by antibiotics such as penicillin, ceftriaxone, etc., and physical cooling can also be used to reduce the fever, in addition, the etiology of the disease is more important. Diffuse large b-cell lymphoma is one of the most common malignant lymphomas in clinic, and is an aggressive lymphoma originating from B cells. Clinical manifestations include progressive lymph node enlargement, pain, and systemic symptoms such as night sweats and fever. Treatment is mainly based on chemotherapy. 1. Infection: in case of fever caused by infection, the cause of infection should be determined in time and anti-infection treatment such as penicillin and ceftriaxone should be taken actively. 2. Physical hypothermia: if the body temperature does not exceed 38.5 ℃, you can use wipes, antipyretic patches and other methods to reduce fever, moderate amount of drinking water, but also hot water foot soak, etc. can help to lower the body temperature. 3. Etiological treatment: Rituximab, vincristine, cyclophosphamide and other drugs should be given as chemotherapy. Fever of diffuse large b-cell lymphoma is more often caused by the disease itself, so targeted radiotherapy and chemotherapy for diffuse large b-cell lymphoma can solve the problem of fever fundamentally. Specific diagnosis and treatment should be carried out under the guidance of a physician.